Men are better than women is characterized by pain and experience greater stress when they are repeated.
Many researchers around the world currently developing various methods of patients get rid of chronic pain. But in order to find the “antidote”, we first need to understand the nature of chronic pain,reports News.
Experts have found that one of the “driving forces” chronic pain can be memories of unpleasant sensations experienced by the patient earlier. A new work by canadian researchers shows that these memories depend directly on gender.
Previously it was shown that men and women with chronic pain is different. It is logical that they may be different and its perception, scientists argue.
To test this hypothesis, they conducted a series of experiments, first with model animals (mice), and then with people.
In the first stage of female and male rodents were placed in a special container, then the influence of warmth on the back foot, which should cause a little pain. Its level was assessed by how quickly the animal ran off from the heat source.
The researchers then cause rodents intense pain with an injection of diluted vinegar. For about 30 minutes, the mice were tortured and abdominal pain.
The next day of the animals was placed in the same container and repeated the first “execution”. Observations have shown that males have a thermal impact caused a more powerful pain than females, as well as what they have themselves a day earlier.
Meanwhile in males, which was placed in a new container, do not serve a “torture chamber” earlier, the discomfort intensified.
Followed by similar testing involving human subjects: 41 men and 38 women aged 18 to 40 years. They were brought into the room and was also subjected to unpleasant heat, but in the forearm. The participants were asked to rate the level of pain on a 100-point scale.
Immediately afterwards they were asked to wear a cuff for measuring blood pressure on the same arm that had been exposed, and within 20 minutes to do this hand movement, as during sports training. Only seven people out of nearly 80 put such feelings a score below 50 points.
The next day some of the participants returned to the same room, and the other part visited the new. Again, volunteers were subjected to thermal effects. Men that are in the same room as before, rated pain as more severe compared with all women and men who are “heated” in a strange room.
The authors admit that was amazed when I saw that between men and women observed the same differences, and that between males and females mice.
“Even more surprising was the fact that men react stronger. It is well known that women are more sensitive to pain than men, and they tend to be more susceptible to stress,” said co-author psychologist Lauren Martin (Loren Martin) from the University of Toronto MISSISSAUGA.
But the results show that in fact men are better at remembering pain and experiencing more stress when they are repeated.
“There were reasons to expect that we will see increased sensitivity to pain on the second day, but there was no reason to believe that it will be typical for men. It was a complete surprise,” said one of the lead authors of the study Professor Jeffrey Graves (Jeffrey Mogil) from McGill University.
According to him, most likely, the second phase of the experiment male mice and men expected, consequently, any new injection of vinegar or another “round” with cuffs. This “anticipation” has caused a lot of stress, which has increased discomfort even from not-so-painful heat exposure.
To confirm these findings, the team conducted another test, only with mice. The scientists injected the rodents a drug that blocks memory. When they repeated the experiment, we saw that the males were no signs of increased pain reactions in the second stage. Obviously, because they were not frightened by the memories and not stress about after the previous discomfort.
“This is an important conclusion, because more and more evidence suggests that chronic pain is a problem in the extent to which you remember her. In this study, the first such “memorable pain” was studied using a translational approach – with both rodents and people,” said Martin.
According to him, if memories are the “driving force” of chronic pain, it is important to understand how such memories are formed.
The authors are optimistic in the future based on new data we intend to develop effective methods of dealing with chronic pain to make life easier for many patients.