Researchers consider this experiment as a model of informational stress of people living in large cities.
An international team of scientists with participation of specialists of Moscow state University named after M. V. Lomonosov for the first time with the help of ultrasounds cause mice emotional stress and study its implications for the brain and other body systems,reports TASS.
The obtained results will be useful in the treatment of emotional distress among residents of Metropolitan areas, reported on Thursday the press service of the Moscow state University.
“An international team of scientists with participation of specialists of Moscow state University named after M. V. Lomonosov with the assistance of ultrasounds in mice caused emotional stress and study its physiological consequences. This model can be further used for prospecting and testing of new drugs and a better understanding of the mechanisms of emotional stress”, – stated in the message.
Previously it was thought that emotional stress is exclusively a human trait, to model it in animals was not possible, for this reason, the physiological consequences of this kind of stress to the body have been studied very little. Now scientists were able to simulate emotional stress in mice – an animal from the experimental group were exposed to ultrasound of different frequencies. After three weeks of the experiment, the researchers conducted behavioral tests that showed that rodents are more anxious and aggressive. In addition, they changed the genes associated with the production of “happiness hormone” serotonin, which is also responsible for the daily cycles of sleep and wakefulness.
The scientists also examined changes in the brains of rodents and found changes in the number and density of cells, which is usually when injuries or diseases. In addition to changes in the level of gene expression in mice from the experimental group in the brain tissue and in plasma was increased the content of anti-inflammatory signaling molecules. Together all of these molecular signs indicate the start of the inflammatory processes and reducing the rate of formation of new neurons and neural connections.
The study’s lead author Dmitry Pavlov said that scientists have considered ultrasonic stress as a rodent model of information stress of people living in large cities.
“As among the modern inhabitants of big cities are increasingly recorded the psychoemotional diseases, further study of this Protocol will assess the role of emotional stress in affective disorders. This is critical for the development of targeted therapy of a wide spectrum of mental and emotional diseases associated with the influence of the information-enriched environment for residents of cities” – quoted by his press service.