Men are more prone to hypertension and heart attacks because of differences in the genes responsible for the biorhythms and controlling daily fluctuations of pressure in the blood vessels. To such conclusion the geneticists who published the results of experiments on mice, American Journal of Physiology.
“Our bodies all contain a kind of biological clock that control their work and adapting them to a 24-hour cycle of life. These include heart and disruption of these rhythms lead to the development of serious diseases. We showed that female mice are protected from such consequences,” — says Lauren Duma from the University of Florida in Gainesville,RIA Novosti reported.
According to who statistics, the average life expectancy of a person today is 71. In all countries, from the poorest countries in Africa to the richest countries of Europe, life expectancy for women remains higher than men 73 vs 68 years.Recently, scientists have discovered that this “gender gap” is associated not only with the tendency of men to risk and bad habits, but also to the fact that they are much more likely to die from heart attacks, ischemia and other heart disease related to hypertension or atherosclerosis. On average, they affect older men about 3.5 times more often than women, and this figure is growing.
Such discoveries, according to the Council, further increased the interest of molecular biologists and geneticists to how could be these differences and what changes in the level of activity of genes they may be associated. For example, her team studied the unusual phenomenon of linking failures “of biological clock” of the body, however, how well the heart is working.
The fact that the pressure in the vessel rises or falls not only with the appearance or disappearance of stress on the body, but also over time. As a rule, in a healthy person it is a little higher during the day and slightly lower during the night. The absence of this decrease, statistics show that especially typical for men and is associated with increased chance of getting heart failure and dying at an early age.
Duma and her colleagues tried to find out why women don’t suffer from these problems, disabling the genes that control the operation of the biological clock in the cells of the heart, in the DNA of normal laboratory mice are not predisposed to the development of hypertension and other diseases.These experiments showed that deletion or damage to one of them, PER1 plot, almost certainly led to the development of abnormalities in diurnal pressure variation in males, but had no effect on the lives of females.
Interestingly, this protective effect disappears if researchers blocked the production of sex hormones or have removed the ovaries of mice. Further study of PER1 and on which cell types and the genes it affects, as I hope genetics will help to understand what protects women from heart disease and blood vessels and how this effect can be applied to all men.