Chronic fatigue may indicate problems with the immune system


 Хроническая усталость может указывать на проблемы с иммунитетом

Scientists admit that the excessive activity of the immune system can cause changes in the metabolism or the muscular system, which makes people feel tired.

Scientists admit that the excessive activity of the immune system can cause changes in the metabolism or the muscular system, which makes people feel tired, UNIAN reports.In scientific literature this phenomenon is sometimes called malvicini encephalomyelitis, writes The Guardian. New research has found that the appearance of the syndrome can stand overly active immune system. It is acceptable that a specific virus or a chronic illness can trigger such condition.”The evidence is insufficient. However, there are studies that indicate elevated levels of inflammatory markers. However, such abnormalities are not constantly”, – said the scientist king’s College London Alice Russell.Russell and her colleagues describe an experiment in which participated 55 patients-volunteers with chronic hepatitis C. For treatment during the period from 6 to 12 months they have conducted injections of interferon alpha, a protein that is naturally secreted in the body and stimulates white blood cells to provoke the immune system response. This treatment has previously been associated with the occurrence of chronic fatigue syndrome as a side effect. The course helped the majority of participants of the experiment to overcome hepatitis. But they all spoke of undue fatigue during treatment, which disappeared when the injections stopped.However, six months after the course in 18 of the participants still had the chronic fatigue syndrome. As it turned out, before the treatment they had elevated levels of protein associated with inflammation called IL10. After four weeks of treatment, the level of this protein and another called IL6 was two times higher than those of people who have completed the course without feeling groundless fatigue. But after six months of injections of interferon alpha between the two groups of patients there was no difference.

According to Professor Carmine Pariante, the fact that at the time of detection of chronic fatigue syndrome immune stimulation no longer occurred.”And that is why we are unable to find decisive evidence for immune activation in people with chronic fatigue syndrome,” explained he, adding that the increased activity of the immune system can cause changes in the brain, muscles and metabolism, which lead to feelings of fatigue, though it is hard to tell.

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